Brain After Experimental Intracerebral Hemorrhage in Rat Glutamate Receptor Blockade Attenuates Glucose Hypermetabolism in Perihematomal
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چکیده
Timothy D. Ardizzone, Aigang Lu, Kenneth R. Wagner, Yang Tang, Ruiqiong Ran and Frank Brain After Experimental Intracerebral Hemorrhage in Rat Glutamate Receptor Blockade Attenuates Glucose Hypermetabolism in Perihematomal Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000143451.14228.ff 2004;35:2587-2591; originally published online September 16, 2004; Stroke. http://stroke.ahajournals.org/content/35/11/2587 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in rat.
BACKGROUND AND PURPOSE Intracerebral hemorrhage has no effective treatment. The delayed appearance of edema, apoptosis, and inflammation in perihematomal brain suggests that these events may be targets for therapeutic intervention. To develop successful treatments, we must learn more about the effects of hemorrhage on brain tissue. In this study, we investigated the acute metabolic effects of i...
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OBJECTIVE To observe the relationship between the perihematomal glutamate levels and the blood-brain barrier (BBB) permeability in a rabbit model of intracerebral hemorrhage (ICH). METHODS Seventy-two rabbits were randomly divided into an intracerebral hemorrhage (ICH) model group and a normal control (NC) group, and each group of 36 rabbits was subsequently divided into 6, 12, 18, 24, 48 and...
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BACKGROUND AND PURPOSE Hyperglycemia has a deleterious effect on brain ischemia. However, the effect of hyperglycemia in intracerebral hemorrhage (ICH) is not well known. We investigated the effect of hyperglycemia on the development of brain edema and perihematomal cell death in ICH. METHODS Hyperglycemia was induced by intraperitoneal injection of streptozotocin (60 mg/kg) in adult Sprague-...
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BACKGROUND AND PURPOSE Progressive perihematomal cell death over 3 to 4 days has been described after experimental intracerebral hemorrhage (ICH). We investigated whether progressive perihematomal damage occurs in human subjects by measuring relative changes in regional cerebral glucose metabolism with (18)F-fluorordeoxyglucose (FDG) positron emission tomography at multiple time points during t...
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Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. After ICH, the immediate infiltration of leukocytes and activation of microglia are accompanied by a rapid up-regulation of the 18-kDa translocator protein (TSPO). TSPO ligands have shown anti-inflammatory and neuroprotective properties in models of CNS injury. In this study, we determined the impact of a TSPO ...
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